O-304 (ATX304) Capsules 50mg

Buy O-304 (ATX304) Capsules 50mg | High-Purity AMPK Activator UK

Welcome to the UK’s leading source for high-performance laboratory ligands. Our O-304 (also cataloged as ATX304) 50mg capsules provide researchers with a highly stable, pre-measured format of this ground-breaking small molecule. Formally classified as 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide ($C_{16}H_{11}Cl_{2}N_{3}O_{2}S$), O-304 stands out in the field of biochemical research due to its distinct mechanism of action.

Unlike traditional metabolic compounds that indirectly trigger cellular pathways by altering adenosine triphosphate (ATP) ratios or causing cellular stress, ATX304 acts as a direct, non-nucleoside pan-AMPK activator. It works by targeting the $\alpha$, $\beta$, and $\gamma$ subunits of the AMPK trimer, preventing the dephosphorylation of pAMPK at the critical Threonine-172 ($Thr^{172}$) site. This effectively locks the enzyme into its active state, allowing for precise tracking of downstream metabolic switches, lipid transport dynamics, and cellular longevity signaling without depleting vital cellular energy reserves.

Core Benefits in Biochemical Research

Deploying our 50mg O-304 capsules into your research models unlocks several critical investigative pathways:

• Advanced Metabolic Re-programming: Provides a dependable baseline to study fatty acid oxidation pathways, glucose uptake regulation in skeletal muscles, and the inhibition of hepatic lipid synthesis.

• Cardiovascular and Microvascular Insights: Enables extensive investigation into how direct AMPK activation impacts vascular endothelial health, changes hyperfiltration rates, and influences systemic blood pressure modulations.

• Mitochondrial Autophagy and Homeostasis: Serves as a primary reference point for studying cellular aging, mitochondrial renewal, and stress resistance pathways under simulated metabolic conditions.

• Pre-formulated Convenience: Individual 50mg capsules eliminate the ambient humidity risks, static powder loss, and measurement variances often associated with handling raw, bulk crystalline powders during initial master-mix steps.

Uncompromised Purity Standards

Quality control is paramount in biochemical synthesis. Every batch of our ATX304 capsules undergoes rigorous analytical testing via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee a minimum chemical purity of 98.0%.

We certify that our products are entirely free from residual heavy metals, cross-contaminating reagents, or unreacted synthetic precursors. By purchasing your research compounds from us, you ensure that your experimental data remains clean, reproducible, and completely free from foreign chemical interference.

Usage and Solubility Information

Important Regulatory Notice: This product is supplied exclusively as a reference standard and laboratory reagent for biochemical research. It is strictly not intended for human consumption, diagnostic medical procedures, or direct veterinary application.

For in vitro laboratory protocols, O-304 exhibits highly specific solubility metrics. It is fully soluble in dimethyl sulfoxide (DMSO) at concentrations ranging between 20 mg/mL to 30 mg/mL. Please note that this crystalline compound is completely insoluble in water and pure ethanol. For in vivo animal model preparations or mechanical assays, the compound is typically suspended uniformly in a vehicle solution, such as a 0.5% carboxymethylcellulose sodium (CMC-Na) solution or a multi-solvent matrix containing 10% DMSO and 90% corn oil, added sequentially to establish a stable, homogeneous suspension.

Storage and Structural Stability

To preserve the molecular structural integrity of the thiadiazol-benzamide core, strict storage parameters should be maintained:

• Dry Capsule Storage: Keep the capsules in their original, tightly sealed, moisture-proof containers at $-20^{\circ}\text{C}$ to ensure a shelf-life stability of up to 3 years.

• Stock Solution Management: Once dissolved in a fresh, anhydrous DMSO solvent, the resulting liquid stock solutions must be aliquoted immediately into airtight vials and stored at $-80^{\circ}\text{C}$ to mitigate degradation over a maximum period of 6 months. Avoid repeated freeze-thaw cycles.

Lab Testing and Documentation

Transparency underpins valid scientific study. Every shipment of O-304 50mg capsules is accompanied by its corresponding batch-specific Certificate of Analysis (CoA). This document provides full clarity on the analytical breakdown, including verified HPLC chromatograms and exact molecular weight validations ($380.25\text{ g/mol}$).

Material Safety Data Sheets (MSDS) detailing handling precautions, personal protective equipment (PPE) recommendations, and environmental disposal protocols are readily available for download or included upon request with your delivery.

Fast and Secure UK Shipping

We provide streamlined, reliable shipping solutions across the United Kingdom. All shipments are packed in heavy-duty, tamper-evident, and temperature-buffered packaging to prevent any structural breakdown during transit.

Orders are shipped via fully tracked courier networks, ensuring secure delivery directly to your university laboratory, private research facility, or biotech enterprise. Orders received before our standard afternoon cutoff are processed and dispatched the same day, complete with real-time tracking references emailed straight to your procurement team.

Frequently Asked Questions (FAQs)

What is the exact difference between O-304 and ATX304?

There is no chemical difference. O-304 and ATX304 are synonym identifiers for the exact same unique molecular entity, recognized under the chemical registry number CAS 1261289-04-6.

Can this compound be dissolved directly in a saline solution?

No. O-304 is highly hydrophobic and completely insoluble in water, saline, or aqueous buffers. It must be pre-dissolved in an organic solvent like DMSO or blended into a structured oil/surfactant suspension before introduced into an aqueous environment.

Is a license required to buy O-304 capsules in the UK?

As a non-scheduled research chemical intended purely for laboratory and in vitro evaluation, O-304 does not require a specialized domestic license to purchase for institutional research purposes. However, buyers must verify their institutional status, as we do not sell to private individuals or patients.

What is the primary advantage of a pan-AMPK activator over specific isoform activators?

A pan-AMPK activator simultaneously stimulates all structural combinations of the AMPK complex ($\alpha 1/\alpha 2$, $\beta 1/\beta 2$, $\gamma 1/\gamma 2/\gamma 3$). This provides a comprehensive systemic window into global cellular energy regulation rather than limiting the metabolic observation to tissue-specific variants.