SS-31

Buy SS-31 Peptide UK | High-Purity Research Lyophilised Powder

Welcome to the UK’s premier source for ultra-pure research peptides. Our SS-31 (also known in clinical literature as Elamipretide or Bendavia) is a small, cell-permeable, synthetic tetrapeptide designed specifically for targeting the inner mitochondrial membrane.

Mitochondria serve as the primary power plants of eukaryotic cells, converting nutrients into adenosine triphosphate (ATP) through oxidative phosphorylation. However, during states of cellular stress, these systems can degrade, leading to accelerated reactive oxygen species (ROS) production and mitochondrial decay. SS-31 represents a cutting-edge class of compounds engineered to address this exact mechanism.

Our SS-31 is supplied as a highly stable, white lyophilised (freeze-dried) powder in clear, vacuum-sealed glass vials. By choosing our UK-based repository, you eliminate the risks of international customs delays, high import VAT, and degraded shipments. We cater exclusively to UK universities, biochemical laboratories, and independent institutional researchers requiring uncompromised molecular consistency.

Key Benefits in Research Environments

SS-31 has generated immense interest across UK biomedical circles due to its unique structural affinity for mitochondrial lipids. Research applications focus heavily on the following biochemical pathways:

• Cardiolipin Targeting: Unlike non-specific antioxidants, SS-31 binds selectively to cardiolipin—a polyunsaturated phospholipid uniquely located on the inner mitochondrial membrane. This interaction prevents cardiolipin from undergoing oxidative damage.

• Mitochondrial Structural Integrity: Studies demonstrate that by anchoring to cardiolipin, SS-31 helps preserve the structural curvature of cristae, maintaining the architectural matrix necessary for optimal electron transport chain performance.

• Reduction of Oxidative Stress: By optimizing electron transfer, the peptide drastically mitigates the leakage of electrons, resulting in a measurable down-regulation of intracellular reactive oxygen species (ROS).

• ATP Production Enhancement: In models of ischemia or tissue stress, SS-31 has shown a profound capacity to restore depleted ATP levels, protecting cellular viability without causing systemic toxicity.

• Neuroprotective Studies: UK research initiatives frequently leverage SS-31 to evaluate its efficacy in models of neurodegenerative decline, assessing how metabolic preservation influences cognitive tissue degradation.

Purity and Quality Assurance

In scientific research, analytical accuracy is paramount. Substandard peptides with residual TFA (trifluoroacetic acid), heavy metals, or structural isomers yield corrupted data.

[Batch Specification Thresholds]
Purity (HPLC):        ≥ 99.0%
Identity (MS):        Matches Reference Sequence
Appearance:           Lyophilised White Powder
Moisture Content:     ≤ 5.0%

Every single batch of SS-31 distributed by our UK facility undergoes exhaustive quality control testing. We run High-Performance Liquid Chromatography (HPLC) to verify purity and Mass Spectrometry (MS) to confirm exact molecular weight and sequence identity. We refuse to compromise: if a batch falls even a fraction below 99.0% purity, it is rejected immediately. Certified copies of the analytical documentation are available upon request for institutional procurement verification.

Usage and Reconstitution Info

This product is supplied as a freeze-dried solid and must be accurately reconstituted prior to laboratory analysis.

For optimal stability and sequence conservation, reconstitution should be carried out using sterile, bacteriostatic water or laboratory-grade phosphate-buffered saline (PBS).

1. Allow the SS-31 vial to acclimate to ambient room temperature before introducing any solvent. This avoids internal condensation.

2. Using a sterile syringe, gently introduce the chosen diluent down the glass wall of the vial. Do not spray directly onto the lyophilised cake.

3. Swirl the vial in a smooth, circular motion. Do not shake. Shaking induces shearing forces that can damage the peptide’s secondary structural layout and lead to denaturation.

4. Once fully dissolved, the solution should be clear, transparent, and entirely free of particulate matter.

Storage Guidelines

To maintain maximum peptide viability over extended timelines, strict adherence to temperature thresholds is required:

• Lyophilised Powder (Long-term): Store at $-20^{\circ}\text{C}$ or below. Under these conditions, the un-reconstituted peptide remains completely stable for up to 24 months.

• Lyophilised Powder (Short-term): Refrigerate at $2^{\circ}\text{C}$ to $8^{\circ}\text{C}$ if use is scheduled within 3 months.

• Reconstituted Liquid Solution: Must be stored continuously between $2^{\circ}\text{C}$ and $8^{\circ}\text{C}$. For optimal experimental results, use within 14 days of dissolution. If extended liquid storage is required, divide the solution into single-use aliquots and freeze immediately at $-20^{\circ}\text{C}$ to prevent repeated freeze-thaw degradation cycles.

Lab Testing and Verification

Transparency builds scientific trust. Every vial of SS-31 we ship features an assigned batch number cross-referenced with its corresponding independent lab reports. Our testing protocols check for residual solvents, bacterial endotoxins, and structural purity. This guarantees that your assays are free from confounding variables, enabling clean, repeatable data for your publications or laboratory logs.

UK Shipping and Handling

We understand that timing is critical to maintaining laboratory workflows.

• Domestic Discretion: All shipments are packaged in unmarked, temperature-buffered padded boxes to preserve privacy and structural stability during transport.

• Delivery Speed: Orders placed before 3:00 PM GMT Monday through Friday are dispatched the same day via Tracked Royal Mail Special Delivery or premium next-day couriers.

• Customs-Free: Because our supply base is located directly within the UK, you face zero customs inspections, zero import taxes, and absolute delivery certainty.

❓ Frequently Asked Questions (FAQs)

Disclaimer: All products listed on this website are intended solely for laboratory research, in vitro evaluation, and academic studies. They are strictly not for human or animal consumption.

What is the primary mechanism of action for SS-31?

SS-31 targets the inner mitochondrial membrane where it binds selectively to cardiolipin. This structural stabilization prevents cardiolipin from interacting with oxygen radicals, thereby maintaining electron transport efficiency and preventing cellular apoptosis.

What is the difference between SS-31 and Elamipretide?

There is no chemical difference. SS-31 is the standard laboratory designation code, while Elamipretide is the non-proprietary international medicinal name assigned to the exact same peptide sequence.

How do you guarantee that the peptide doesn’t degrade during UK shipping?

Our lyophilisation process extracts all residual air and moisture from the vial, creating a stable vacuum environment. This form allows the peptide to withstand short-term ambient temperature fluctuations during domestic transit without losing its biochemical potency.

Can I get a copy of the HPLC report before I order?

Yes. Our customer support team can provide the specific batch analysis data sheets for any of our current inventory items. Simply reach out via our institutional contact page.